A COLD CASE REVIEW combined with advances in forensic technology have helped bring a knifepoint rapist to justice after 35 years. Michael O'Meara from Coventry in the West Midlands initially denied the allegations against him but ultimately pleaded guilty. The 58-year-old has now been jailed for 12 years over the 1989 attack in the city. "This was a harrowing and horrific attack which O'Meara truly believed he had gotten away with," said DC Ryan Ahern of West Midlands Police. On the day of the offence in July 1989, the woman O'Meara attacked had been in Coventry city centre with friends. While walking down Silver Street looking for a taxi, O'Meara dragged her into a secluded area and raped her at knifepoint. Despite an extensive investigation at the time, no trace of a suspect was found for more than three decades until a cold case review was carried out this year. Forensic evidence gathered at the time of the attack was re-examined and, due to significant advances in forensic technology, was linked to O'Meara. With a full DNA profile now available, O'Meara — who had previous convictions for sexual assault dating back to the 1990s — was arrested. Despite denying the offence in interview, he was charged and pleaded guilty on November 7 and at Warwick Crown Court on December 9, was jailed for 12 years for rape. DC Ahern said that 'significant leaps forward in forensic science' in the years since the attack allowed the evidence to be re-examined, proving O'Meara's guilt. "On behalf of the whole team involved in this investigation, we hope the survivor of this attack can find some closure knowing justice has finally been done," he added. "We have dedicated officers across the West Midlands whose job it is to investigate non-recent sex offences. "No matter how long ago the offence happened, we encourage all survivors to come forward and tell their story with the promise we will investigate any possible lines of enquiry." See More: Coventry, West Midlands, West Midlands PoliceSir Keir Starmer has been warned by a trade union not to impose “blunt headcount targets” for the size of the Civil Service but Government sources insisted there would be no set limit, although the number “cannot keep growing”. Departments have been ordered to find 5% “efficiency savings” as part of Chancellor Rachel Reeves’ spending review, potentially putting jobs at risk. The size of the Civil Service has increased from a low of around 384,000 in mid-2016, and the Tories went into the general election promising to reduce numbers by 70,000 to fund extra defence spending. Any reduction under Labour would be more modest, with the Guardian reporting more than 10,000 jobs could be lost. A Government spokesman said: “Under our plan for change, we are making sure every part of government is delivering on working people’s priorities — delivering growth, putting more money in people’s pockets, getting the NHS back on its feet, rebuilding Britain and securing our borders in a decade of national renewal. “We are committed to making the Civil Service more efficient and effective, with bold measures to improve skills and harness new technologies.” Mike Clancy, general secretary of the Prospect trade union said: “We need a clear plan for the future of the civil service that goes beyond the blunt headcount targets that have failed in the past. “This plan needs to be developed in partnership with civil servants and their unions, and we look forward to deeper engagement with the government in the coming months.” A Government source said: “The number of civil servants cannot keep growing. “But we will not set an arbitrary cap. “The last government tried that and ended up spending loads on more expensive consultants.” The Government is already risking a confrontation with unions over proposals to limit pay rises for more than a million public servants to 2.8%, a figure only just over the projected 2.6% rate of inflation next year. Unions representing teachers, doctors and nurses have condemned the proposals. In the face of the union backlash, Downing Street said the public sector must improve productivity to justify real-terms pay increases. The Prime Minister’s official spokesman said: “It’s vital that pay awards are fair for both taxpayers and workers.” Asked whether higher pay settlements to staff would mean departmental cuts elsewhere, the spokesman said: “Real-terms pay increases must be matched by productivity gains and departments will only be able to fund pay awards above inflation over the medium-term if they become more productive and workforces become more productive.” TUC general secretary Paul Nowak said: “It’s hard to see how you address the crisis in our services without meaningful pay rises. “And it’s hard to see how services cut to the bone by 14 years of Tory government will find significant cash savings. “The Government must now engage unions and the millions of public sector workers we represent in a serious conversation about public service reform and delivery.”
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AI Could Be Making Scientists Less CreativeEuropean Parliament President and Maltese MEP Roberta Metsola is featured in Google’s ‘Year in Search 2024’ video, an annual retrospective look at topics searched using the platform. Metsola appears briefly in a segment called ‘breakout elections’, with a clip of her casting her vote at a Sliema primary school. The section also features footage of other women voting, American president-elect Donald Trump and UK Prime Minister Kier Starmer. In a voiceover accompanying the segment, Metsola can be heard saying, “2024 will be the biggest global election year in history.” More than two billion people across 50 countries – including seven of the most populous nations – were expected to go to the polls this year, to news outlet . While the US election arguably dominated the international media landscape, closer to home Europe was also gripped by election fever as the public cast their votes in the European Parliament elections. In Malta, Labour won but saw its majority , losing its fourth MEP to the Opposition Nationalist Party while securing less than half the votes. Fortune continued to favour EP president Roberta Metsola, however, who a last-minute challenge from Spanish MEP Irene Montero to be overwhelmingly re-elected to a second term in the strongest win for an EP president in history. Meanwhile, in local council elections held at the same time but with results announced later, the Labour Party saw losses but still managed to of 39 local councils, well over half of Malta’s 68 localities. Across the pond, last month Donald Trump claimed a " " victory over Democrat Kamala Harris in what has been called one of the most stunning comebacks in US political history. Aside from politics, the Google video also shows clips from talk shows and social media, sporting events and music concerts, while taking a look at some of the scientific and technological advancements in the past year. More sombre topics are also covered, however, such as the devastating impacts of September’s Hurricane Helene on the Southeastern United States and those addressing mental health issues. Actors Maggie Smith and James Earl Jones, who died this year, also feature. The video is the latest in a series of annual videos going back at least as far as 2014, according to a YouTube – owned by Google – page featuring uploads related to the hashtag ‘#YearinSearch’. Such look-backs are increasingly common on technology platforms and in mobile applications, with other examples including Spotify’s ‘Spotify Wrapped’ viral marketing campaign and Google Photos’ ‘Recap’ feature. You can unsubscribe at any time by clicking the link in the footer of our emails. We use as our marketing platform. By subscribing, you acknowledge that your information will be transferred to Mailchimp for processing.
A backlog of over 1,000 unsolved cold cases sits in the Fort Worth Police Department's Cold Case Unit. Now, a proposed bipartisan bill could help provide the funding needed to solve these cases and bring closure to families of lost and missing loved ones. The Carla Walker Act, introduced by Sen. John Cornyn (R- Texas) and Sen. Peter Welch (D-Vermont), is named after Fort Worth murder victim Carla Walker. Walker was 17 years old when she was abducted, held captive, sexually assaulted and eventually murdered in 1974. In 2020, 46 years after her death, a suspect was identified using advanced forensic analysis. Glen McCurley, the suspect, would plead guilty to her murder less than a year later. The bill would provide funding to police agencies for the same advanced testing used in Walker's case. Several cases across North Texas have been solved using these methods that allow scientists to examine DNA samples more closely and search for family members that may share that DNA. This allows for investigators to build family trees that can lead to suspects. "We know all of our law enforcement agencies are under-staffed and under-funded and they don't necessarily have access to the latest technology," Cornyn said in an interview with NBC 5. "This would provide additional federal funds so that police departments around the country, forensic labs, could access this innovative, new technology to allow them to crack these cold cases and to bring the perpetrators to justice." Last month, NBC 5 Investigates looked into the backlog of cold cases in Fort Worth . Families said they felt forgotten because the Fort Worth Cold Case Unit is understaffed. The department confirmed that only one full-time detective and two part-time reserve officers were assigned to the unit, which has 1,000 cold cases to solve. Retiring Police Chief Neil Noakes said his department is actively working on cold cases where new leads exist. In September, NBC 5 Investigates reported that the Fort Worth Police Department's crime lab has been so short-staffed that it failed to meet state deadlines for processing evidence in sexual assault cases more than 1,200 times . On Nov. 21, Cornyn announced that the federal government was sending $2.1 million to clear the backlog in Fort Worth. The Dallas Police Department also has a backlog of more than 3,000 cold case homicides. On Friday, the Dallas County District Attorney's Office secured over $3.8 million in federal grants for cold cases. The funding would create two units: the SAKI Unit (Sexual Assault Kit Initiative) and the Cold Case Homicide Unit. “This grant money will allow us to apply more resources to solve more violent crimes and solve them faster than ever before,” said District Attorney John Creuzot. “This is an incredibly profound time for the people of Dallas County to finally get justice for some of the worst crimes committed against our citizens.” Cornyn confirmed to NBC 5 that he believes that funding from the Carla Walker Act would help with backlogs like Dallas and Fort Worth's. The Carla Walker Act was previously introduced in the U.S. House in 2022 by former Representative Kelly Armstrong (R-North Dakota). It was referred to a House Judiciary Committee but never made it to the floor.Purdy injured his right shoulder in last Sunday's loss to the Seattle Seahawks . Purdy underwent an MRI that showed no structural damage but the shoulder didn't improve during the week and Purdy was ruled out for the game. Coach Kyle Shanahan said star defensive end Nick Bosa also will miss the game with injuries to his left hip and oblique. Left tackle Trent Williams is questionable with an ankle injury and will be a game-time decision. This will be the first time Purdy has missed a start because of an injury since taking over as the 49ers’ quarterback in December 2022. Brandon Allen will start in his place. The Niners (5-5) are currently in a three-way tie for second in the NFC West, a game behind first-place Arizona, and have little margin for error if they want to get back to the playoffs after making it to the Super Bowl last season. Purdy has completed 66% of his passes this season for 2,613 yards, 13 TDs, eight interceptions and a 95.9 passer rating that is down significantly from his league-leading mark of 113 in 2023. Allen has been mostly a backup since being drafted by Jacksonville in 2016. Allen last started a game in Week 18 of the 2021 season for Cincinnati and has thrown just three passes the last three seasons — including none since joining San Francisco in 2023. Joshua Dobbs will be the backup on Sunday. AP NFL: https://apnews.com/hub/NFL
WASHINGTON — China's retaliatory export controls could take a toll on the growing US clean energy sector and its defense industry, analysts said, as a trade tussle escalates between the world's two biggest economies. Beijing announced this week it would ban exports of gallium, germanium and antimony to the United States, targeting materials used for everything from semiconductors to solar cells. Register to read this story and more for free . Signing up for an account helps us improve your browsing experience. OR See our subscription options.A collection of progressive pressure groups have called on the UK Labour government to ‘think differently’ when it comes to childcare. This is based on new analysis that reveals the English local authorities with lowest numbers of childcare places. The survey shows Walsall ranked worst. The associated report extrapolates the data and predicts that at current rate of decline, there will be no childminders left by 2033. The report comes from the Institute for Public Policy Research (IPPR) – an independent charity working towards a fairer, greener, and more prosperous society and Save the Children, which is active in one hundred countries. Concluding the report The childcare challenge: How can the new government deliver a real early education and childcare guarantee? , the campaign organisations state that the UK government must ensure deprived and rural areas are not left behind in forthcoming childcare expansion. In other words, public policy needs to focused on equalising the disparity throughout the UK. The report indicates that the expansion of free childcare currently underway is at risk of not delivering for poorer families. Amongst the poorest fifth of parents with young children, only a third (36 per cent) use formal childcare, compared to double that (73 percent) of the highest earning households. The analysis indicates how the use of formal childcare is highly defined by social class . Over two-thirds of parents of young children who work in professional jobs such as lawyers, doctors and architects use it, compared to less than half of parents in elementary occupations such as cleaners, care workers and hairdressers. Further analysis by the think tank of local access to private and voluntary nurseries as well as childminders – who deliver nearly all provision for children under three years of age – finds significant variation in access to childcare within a reasonable travel time by local authority, with deprived and rural areas the worst off. The more deprived or more rural a local area is, the fewer and lower-quality childcare options families tend to have. The most deprived areas have 32 percent fewer places per child and 25 per cent fewer good places compared to the most affluent areas. Rural areas have 31 percent fewer places and 29 per cent fewer good places compared to inner cities and town centres. For example, three in four children in Walsall live in areas that have some of the worst access to childcare in England. There are significant regional and local variations. For example, parts of the North-East have five times the average ratio of childcare places to children. However, other parts of the same Combined Authority are amongst the least well served in the country. Part of this problem is driven by the falling numbers of childminders. At the current rate – a drop of around 3,000 childminders per year. Another issue is the lack of places in school-based nurseries. Whilst the number of schools offering nursery provision has grown since 2018, the headcount of children in primary school nurseries has reduced by 14 percent (the equivalent of 42,000 children) between 2015/16 and 2023/24. To remediate the situation, the report urgest the Starmer government to adopt progressive and leftwing policies, such as: • Establishing new not-for-profit nursery trusts to rival private equity backed for-profit chains, with the aim of helping smaller childcare providers with business support, best practice and achieve the same economies of scale as larger groups. • Reinvigorating the role of local authorities including by pooling funding to secure new childcare in the areas of greatest need and more actively brokering the new schools-based nursery expansion. • Growing and supporting the supply of childminders by developing a new long-term national strategy which sees them paid monthly to deliver funded entitlements and explores a new childminder friendly national digital platform. • Increasing funding for deprived areas and children through raising the Early Years Pupil Premium and increasing weighting for Additional Need in the national formula. • Reforming the funding system , giving greater recognition to emerging needs in early years within mainstream funding. These proposals attempt to deal with childcare deserts, a lack of funding and the patchwork of commissioning services. Dr. Tim Sandle is Digital Journal's Editor-at-Large for science news.Tim specializes in science, technology, environmental, business, and health journalism. He is additionally a practising microbiologist; and an author. He is also interested in history, politics and current affairs.
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Early adopters can guarantee life-changing rewards in the always exponential field of cryptocurrencies. As we head toward 2025, the sector is bursting with creative ideas ready to revolutionize their particular industries, allowing investors to realize impressive profits. Five of these— Rexas Finance (RXS), Bitget Token (BGB), FLOKI, Theta Network (THETA), and Worldcoin (WLD)—stand out with the potential to yield up to a 9500% ROI. These initiatives offer interesting choices for investors looking for exceptional results since they mix innovative use with commercial traction. Rexas Finance (RXS) Leading the charge in real-world asset (RWA) tokenization, Rexas Finance (RXS) is front and foremost in blockchain invention. Rexas Finance uses blockchain, decentralized finance (DeFi), and artificial intelligence (AI) to allow fractional ownership of tangible and intangible assets, including real estate, gold, and collectibles. This strategy democratizes wealth and gives worldwide investors access to once-unreachable markets. RXS's presale performance highlights its promise. Initially $0.03, the coin has seen a 400% rise from its Stage 1 price to Stage 10 presale price of $0.15. The presale has drawn notable investor interest, with around $26.375 million raised thus far. With experts projecting significant post-launch expansion, RXS will likely show great early returns upon its scheduled listing at $0.20. The project's CertiK audit guarantees the security of its smart contract, strengthening its reputation. Recent CoinMarketCap (CMC) and CoinGecko listings have also helped to increase its profile; a $1 million giveaway drive where 20 lucky participants stand a chance to win $50,000 worth of RXS tokens has raised community involvement. RXS is a top candidate for remarkable return on investment as it keeps grabbing multi-trillion-dollar markets. Bitget Token (BGB) The utility token of the Bitget Exchange, Bitget Token (BGB), has become popular since it is closely associated with one of the trading platforms with the quickest growth. With a market capitalization of $2.25 billion and a price of $1.61, BGB provides consumers with trading fee reductions, staking rewards, and special features, confirming its value in the crypto trading environment. One of the main forces behind BGB's development is Bitget's increasing appeal as a dependable exchange. The token shows good liquidity and considerable market demand since daily trading volume exceeds $81 million. BGB is a good choice for investors looking for significant returns since its acceptance and price will rise as the trade keeps extending its global presence. FLOKI Initially offered as a meme coin, FLOKI has transformed into a genuine project. With a price of $0.000224 and a market cap of $2.15 billion, FLOKI has occupied a position due to its expanding ecosystem for metaverse integration, DeFi apps, and NFTs. The liveliness of FLOKI's community and unique marketing strategies—which have propelled the token to global attention—define its strength. Its expansion of an ecosystem assures FLOKI is more than simply a speculative asset with long-term development-capable practical purposes. Strong relationships and more listings on major exchanges help FLOKI position itself to give investors exceptional profits. THETA, or Theta Network Using a decentralized network, Theta Network is transforming the field of video streaming. Its market capitalization of $2.13 billion, paired with a THETA price of $2.14, encourages users to provide their computer resources and bandwidth, significantly reducing content distribution costs. Strategic alliances between Theta and industrial behemoths like Samsung and Google highlight its legitimacy and appeal. Theta's decentralized approach is becoming increasingly popular as the video streaming market keeps expanding, helping it become a major participant in a multi-billion dollar sector. THETA presents an extraordinary chance for investors to profit from the junction of media technology and blockchain. Worldcoin (WLD) An ambitious initiative called Worldcoin (WLD) seeks to establish a global digital identity system run on blockchain. With a market valuation of $2.05 billion and a current price of $2.90, WLD is attracting interest for its creative combination of crypto with identity verification. Worldcoin's vision of bringing billions of people into the digital economy fits the rising demand for inclusive financial systems. Its daily trade volume of around $1.4 billion shows great market interest. WLD is expected to provide notable profits for early adopters as the initiative extends its worldwide scope. The Path for a 9500% ROI Investing in cryptocurrencies calls for both brilliant timing and cautious examination. Rexas Finance (RXS) is one of the top choices with a possible 9500% ROI by March 2025 because of its innovative use, significant presale momentum, and market traction. Bitget Token (BGI), FLOKI, Theta Network (THETA), and Worldcoin (WLD) each have unique qualities deserving of attention as well. These initiatives highlight the transforming power of blockchain technology in everything from the democratization of asset ownership to the change of trade ecosystems to the decentralization of sectors like video streaming. These cryptocurrencies provide a perfect chance for investors looking for exponential gains to ride the next wave of invention and industry expansion. Website: https://rexas.com Win $1 Million Giveaway: https://bit.ly/Rexas1M Whitepaper: https://rexas.com/rexas-whitepaper.pdf Twitter/X: https://x.com/rexasfinance Telegram: https://t.me/rexasfinance Join our WhatsApp Channel to get the latest news, exclusives and videos on WhatsApp _____________ Disclaimer: Analytics Insight does not provide financial advice or guidance. Also note that the cryptocurrencies mentioned/listed on the website could potentially be scams, i.e. designed to induce you to invest financial resources that may be lost forever and not be recoverable once investments are made. You are responsible for conducting your own research (DYOR) before making any investments. Read more here.( MENAFN - GlobeNewsWire - Nasdaq) Proposed Acquisition strengthens Pharming's late-stage pipeline with a potential first-in-disease asset Abliva's lead product KL1333 is currently in a pivotal clinical trial, with a positive interim analysis achieved, in mitochondrial DNA-driven primary mitochondrial diseases Total transaction value of approximately US$66.1 million No external funding required to fund acquisition and KL1333 development costs Pharming to host a conference call on Monday, December 16, 2024 at 14:00 CET (8:00 am EST) Leiden, the Netherlands, December 15, 2024: Pharming Group N.V. (“Pharming” or“the Company”) (EURONEXT Amsterdam: PHARM/Nasdaq: PHAR) today announced a recommended public cash offer to the shareholders of Abliva AB (“Abliva”) to acquire all issued and outstanding shares of Abliva. Pharming, through its wholly-owned subsidiary Pharming Technologies B.V., offers the shareholders SEK 0.45 in cash per share in Abliva. The transaction is valued at approximately US$66.1 million. Abliva is a biotechnology company, based in Lund, Sweden, focused on developing medicines for the treatment of mitochondrial disease. Abliva's lead product, KL1333, a regulator of the essential co-enzymes NAD+ and NADH, is in a pivotal clinical study (FALCON) in adult patients with genetically confirmed primary mitochondrial disease (PMD) with mitochondrial DNA (mtDNA) mutations who experience consistent, debilitating fatigue and muscle weakness (myopathy), and reduced life expectancy. Over 30,000 patients diagnosed with mtDNA mitochondrial disease would be potentially addressable by KL1333 in the U.S., EU4 (France, Germany, Italy, Spain) and the UK. KL1333 has shown positive clinical effects in a proof-of-concept Phase 1b study, and a pre-planned interim analysis of the ongoing pivotal FALCON trial demonstrated promising differences over placebo in both alternate primary efficacy endpoints. KL1333 has received Fast Track designation in the U.S. and Orphan Drug Designation for the treatment of PMD in the U.S. and EU. Sijmen de Vries, Chief Executive Officer of Pharming, said: “Abliva has made exciting progress developing KL1333, a potential first-in-disease treatment undergoing a pivotal clinical trial that offers new hope to patients with rare mtDNA mitochondrial disease who experience debilitating fatigue and muscle weakness. With over 30,000 addressable patients in the U.S., EU4 and UK, we are excited about the potential of this asset, which achieved a positive interim analysis in the registration trial in July 2024. We believe KL1333 has blockbuster potential in the U.S. alone and can significantly change Pharming's future growth trajectory. We will fund this acquisition using existing cash, and anticipate covering costs to complete the pivotal trial with positive cash flows from our existing business. The acquisition of Abliva would further strengthen our clinical pipeline with the addition of a therapy, with U.S. launch expected in 2028, aligning with our vision to become a leading global rare disease company. We are pleased that Abliva's independent Board of Directors and major shareholders recognize the expertise and value Pharming brings to the development and eventual commercialization of KL1333, and unanimously support this transaction. We look forward to welcoming the Abliva team with their strong expertise in mitochondrial research and drug development and to combining with our resources, capabilities and commercial infrastructure to bring this groundbreaking and important medicine to patients and their healthcare providers.” Transaction highlights Today at 19:45 CET, Pharming announced a recommended cash offer to the shareholders of Abliva AB. Hereby Pharming, through a wholly owned subsidiary, has offered SEK 0.45 in cash for each outstanding share of Abliva (the ''Offer''). The total value of the Offer based on all outstanding 1,611,884,536 shares in Abliva amounts to approximately SEK 725,348,041, or approximately US$66.1 million. The Board of Directors of Abliva unanimously recommends the shareholders of Abliva to accept the Offer. The Board of Directors of Abliva has obtained a fairness opinion from PwC, according to which, based on the assumptions and reservations stated in the opinion, the Offer is fair to Abliva's shareholders from a financial perspective. Pharming has obtained acceptance undertakings from the three largest shareholders, accounting for 49.82% of Abliva's outstanding shares. The Offer is subject to customary regulatory approvals, and Pharming expects to obtain such approvals prior to the end of the acceptance period. Pharming Group N.V. has cash on hand to finance the Offer in full. The acceptance period in the offer is expected to commence on or around January 16, 2025 and to expire on or around February 7, 2025. For information in relation to the Offer, please refer to An offer document will be made public by Pharming shortly before the commencement of the acceptance period. Van Lanschot Kempen N.V. is sole financial advisor and NautaDutilh N.V. and Mannheimer Swartling Advokatbyrå are legal advisors to Pharming in connection with the Offer. Invitation to conference call Pharming to host a conference call on Monday, December 16, 2024, at 14:00 CET (8:00 am EST). The conference call presentation is available on the pharming.com website from 14:00 CET on December 16, 2024 A transcript will be made available on the website in the days following the call. To participate in the conference call, please register in advance using the link below. Once registered, dial-in information and a unique PIN will be provided, allowing access to the call. Conference call dial-in details: Please note, the Company will only take questions from dial-in attendees. Webcast Link: For further public information, contact: Pharming Group, Leiden, the Netherlands Michael Levitan, VP Investor Relations & Corporate Communications T: +1 (908) 705 1696 E: ... FTI Consulting, London, UK Victoria Foster Mitchell/Alex Shaw/Amy Byrne T: +44 203 727 1000 LifeSpring Life Sciences Communication, Amsterdam, the Netherlands Leon Melens T: +31 6 53 81 64 27 E: ... Abliva investors Leo Wei T: +46 (0)709 910 081 E: ... About KL1333 KL1333 has been designed to treat chronic fatigue and myopathy (muscle weakness) in genetically confirmed adult patients with primary mitochondrial disease. Diagnoses can include MELAS-MIDD and KSS-CPEO spectrum disorders as well as MERRF syndrome. The drug candidate is intended for long-term oral treatment. KL1333 has the ability to restore the ratio of NAD+ and NADH, and thus leads to the formation of new mitochondria and improved energy levels. In a cohort of mitochondrial disease patients in a Phase 1a/b study, the patients who received KL1333 showed both improvements in symptoms of fatigue as well as functional improvements. KL1333 is currently being evaluated in a global, potentially registrational, Phase 2 study (the FALCON study) and has received orphan drug designation in both the USA and Europe as well as Fast Track designation in the USA. About the FALCON Study FALCON is a Phase 2, global, randomized, placebo-controlled, potentially registrational study evaluating the safety and efficacy of KL1333 in adult patients with primary mitochondrial disease who experience consistent, debilitating fatigue and myopathy (muscle weakness), the most common and impairing symptoms. A total of 180 patients with mitochondrial DNA mutations who meet the eligibility criteria are randomized 3:2 to receive KL1333 (50mg-100mg) or placebo twice daily for 48 weeks. The two alternative primary endpoints assess consistent fatigue (using the PROMIS® Fatigue Mitochondrial Disease Short Form) and myopathy (using the 30 second Sit-to-Stand test), only one of which must be positive to file for marketing approval. An interim analysis evaluating 24-week data from the first wave of patients confirmed the strong safety profile of KL1333, and both primary endpoints passed futility, meaning that both have the potential to demonstrate benefit in the final analysis of the study. About Abliva AB Abliva discovers and develops medicines for the treatment of mitochondrial disease. This rare and often very severe disease occurs when the cell's energy provider, the mitochondria, do not function properly. The company has prioritized two projects. KL1333, a powerful regulator of the essential co-enzymes NAD+ and NADH, has entered late-stage development. NV354, an energy replacement therapy, has completed preclinical development. Abliva, based in Lund, Sweden, is listed on Nasdaq Stockholm, Sweden (ticker: ABLI). For more information, please visit About Pharming Group N.V. Pharming Group N.V. (EURONEXT Amsterdam: PHARM/Nasdaq: PHAR) is a global biopharmaceutical company dedicated to transforming the lives of patients with rare, debilitating, and life-threatening diseases. Pharming is commercializing and developing an innovative portfolio of protein replacement therapies and precision medicines, including small molecules and biologics. Pharming is headquartered in Leiden, the Netherlands, and has employees around the globe who serve patients in over 30 markets in North America, Europe, the Middle East, Africa, and Asia-Pacific. For more information, visit and find us on LinkedIn . Forward-Looking Statements This press release may contain forward-looking statements. Forward-looking statements are statements of future expectations that are based on management's current expectations and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance, or events to differ materially from those expressed or implied in these statements. These forward-looking statements are identified by their use of terms and phrases such as“aim”,“ambition”, ''anticipate'', ''believe'', ''could'', ''estimate'', ''expect'', ''goals'', ''intend'', ''may'',“milestones”, ''objectives'', ''outlook'', ''plan'', ''probably'', ''project'', ''risks'',“schedule”, 'seek'', 'should'', ''target'', ''will'' and similar terms and phrases. Examples of forward-looking statements may include statements with respect to timing and progress of Pharming's preclinical studies and clinical trials of its product candidates, Pharming's clinical and commercial prospects, and Pharming's expectations regarding its projected working capital requirements and cash resources, which statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to the scope, progress and expansion of Pharming's clinical trials and ramifications for the cost thereof; and clinical, scientific, regulatory, commercial, competitive and technical developments. In light of these risks and uncertainties, and other risks and uncertainties that are described in Pharming's 2023 Annual Report and the Annual Report on Form 20-F for the year ended December 31, 2023, filed with the U.S. Securities and Exchange Commission, the events and circumstances discussed in such forward-looking statements may not occur, and Pharming's actual results could differ materially and adversely from those anticipated or implied thereby. All forward-looking statements contained in this press release are expressly qualified in their entirety by the cautionary statements contained or referred to in this section. Readers should not place undue reliance on forward-looking statements. Any forward-looking statements speak only as of the date of this press release and are based on information available to Pharming as of the date of this release. Pharming does not undertake any obligation to publicly update or revise any forward-looking statement as a result of new information, future events or other information. Inside Information This press release relates to the disclosure of information that qualifies, or may have qualified, as inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation. Attachment MENAFN15122024004107003653ID1108994994 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.
Spending squeeze ‘could cost more than 10,000 Civil Service jobs’ABC chair Kim Williams has been slammed for recent comments made about broadcasters like Joe Rogan, as the national broadcaster undergoes a wave of structural changes. During his first Press Club address, Kim Williams took aim at the podcaster, saying commentators such as Rogan “prey on fear”. Mr Williams was there to deliver a speech calling for greater investment in the ABC, which he said had lost $150 million a year over the past decade, and to talk about the importance of public broadcasting in an age of disinformation designed to sow division. Williams’ tenure as ABC chair comes at a time of deep disruption for the broadcaster, with the departure of many beloved presenters sparking questions about the competency of management. Today, ABC chair Kim Williams on what’s ahead for the broadcaster, and whether he’s in the right job. Socials : Stay in touch with us on Twitter and Instagram Guest : Chair of the Australian Broadcasting Corporation, Kim Williams.
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The largest intergenerational wealth transfer in US history is about to take place — though the vast majority of Americans are unlikely to inherit much money at all. About $US105 trillion ($164 trillion) is projected to be passed down from older generations over the next quarter century, according to research firm Cerulli Associates, an amount roughly equal to global gross domestic product in 2023. Rising stock markets and home prices, as well as inflation, have fattened the estates that members of the baby boom generation are expected to leave their heirs. Credit: Glenn Hunt Rising stock markets and home prices, as well as inflation, have fattened the estates that members of the baby boom generation, born between 1946 and 1964, are expected to leave their heirs. The latest inheritance projection by Cerulli is 45 per cent higher than the 25-year forecast the firm made only three years ago. US gifts and inheritances are expected to total $US2.5 trillion next year alone. “About 80 per cent of the wealth held today is going to be in motion,” Chayce Horton, the lead author of the Cerulli report, said in an interview. “The ratio of wealth expected to be changing hands in the next 25 years is significant, and much greater than what we even saw a decade ago.” Yet even as the assets of millions of ageing Americans are passed on, the share of the US population that will benefit from inherited money has remained static, a sign of how accumulating family wealth has become more concentrated among the most affluent households. At the same time, money passed down from one generation to another accounts for a growing share of the overall wealth of heirs, rising relative to income from work or investments. Inherited money represented about a quarter of the net worth of households that received it, a Bloomberg analysis of the Federal Reserve’s 2022 Survey of Consumer Finances found, up from roughly 10 per cent in the late 1990s. “We’re becoming less of an economy that promotes entrepreneurship and production and more of an economy focused on inheritance and dynasty,” said Chuck Collins, Director of the Program on Inequality and the Common Good at the Institute for Policy Studies. Collins, whose great-grandfather founded the hot dog and lunchmeat maker Oscar Mayer, gave up his inheritance when he was in his twenties. He is now a member of the Patriotic Millionaires, a nonprofit group of affluent Americans that pushes for the wealthy to pay higher tax rates. Receiving any funds from a deceased family member remains the exception in the US, not the rule. Just one in five American households have received a substantial gift, trust or inheritance in recent decades, according to Bloomberg’s analysis. Inherited wealth is expected to become increasingly concentrated among the most affluent, according to Cerulli. The firm estimates that more than half of the wealth transferred between generations through 2048 will come from households with at least $US5 million in investible assets. Only about 2 per cent of US households meet that threshold. The share of the US population that will benefit from inherited money has remained static, a sign of how accumulating family wealth has become more concentrated among the most affluent households. Credit: Bloomberg The figures lend support to an idea that has long had currency among economists but that has been difficult to confirm — that the share of overall wealth derived from inheritance is far higher than it appears. A 2017 paper argued that inherited money had accounted for more than half of total wealth in the US and Europe since the 1990s, and that “self-reported inheritance flows are implausibly low.” “Inheritance is still the most important factor in terms of wealth concentration,” said Kaushik Basu, professor of economics at Cornell University and former chief economist at the World Bank. The trillions of dollars set to be passed on in coming years could create more social mobility for younger generations, even though its greater concentration among the wealthiest Americans is likely to create more obstacles for lower-income households and exacerbate inequality. “Markets may still flourish, and overall economic growth may continue, but the polarisation between the born-poor and born-rich will become more acute,” Basu said. He added that many of the economic advantages of family wealth are conferred indirectly, through access to education and other opportunities. As more members of the massive baby boom generation die, the annual rate at which wealth is being passed on is expected to increase until the end of the decade. Millennials, born between 1981 and 1996, are expected to inherit more than $US45 trillion by 2048, including some $US3.9 trillion that year alone. Generation X, sandwiched between the baby boomers and millennials, will see their annual inheritance levels peak in 2038 at just shy of $US2 trillion, according to Cerulli. ‘Markets may still flourish, and overall economic growth may continue, but the polarisation between the born-poor and born-rich will become more acute.’ Wealth isn’t only cascading down to younger generations, it also is moving sideways. Before reaching younger heirs, inheritances are often transferred to surviving spouses and partners. Since women tend to outlive men, they are expected to receive a large share of the fortunes being passed on. “A significant amount of the wealth that is held today is believed to be controlled by men,” said Cerulli’s Horton. As those men die, “we expect that wealth to be much more equitably distributed on a gender basis.” Cerulli estimates that women will inherit nearly half of the total projected value of inheritances over the next 25 years. US tax policy has made it easier for wealthy heirs to hang on to more of the money they inherit. President-elect Donald Trump wants to extend part of his 2017 tax-cut package that doubled the estate-tax exemption from $US5.49 million to $US11.18 million. For many older Americans, money handed down from previous generations has shaped their own planning. Alan Jewett, a 75-year-old retiree in Delaware, and his wife received an inheritance of nearly $US3 million from her childless aunts in 2014, after the couple had already put both their children through college and bought a home. “Having money changes the way you look at things in the sense that it gives you and your family a feeling of security,” Jewett said. He and his wife gave part of the inheritance to their kids and set up an irrevocable trust for their three young grandchildren. Some heirs say they have used inherited money to prepare for their own health and elder-care expenses. Lee Robin Gebhardt, a 63-year-old wine seller living in Putnam County, New York, said she invested a $US150,000 retirement account that she received from her father, who died in 2020, in her long-term care. Gebhardt, who plans to work for at least another two years, has enough money put away to last her until she’s 110. “That will take some pressure off my children,” she said. Other relatively wealthy baby boomers have decided to pass on some of their wealth while they’re still able to see its effects for themselves. “I’ve seen an increasing focus on ‘giving while living,’ where people provide for their family’s needs during their lifetime,” said Jared Jones, senior advisor at Omega Wealth Management. “There’s definitely a big focus on not waiting until one passes away to help and witness the benefits of the wealth from the family.” Bloomberg The Business Briefing newsletter delivers major stories, exclusive coverage and expert opinion. Sign up to get it every weekday morning .“We’re aware of the civil allegations and Jay-Z’s really strong response to that,” NFL (National Football League) commissioner Roger Goodell said on Wednesday after the conclusion of the league’s winter meetings. “We know the litigation is happening now. From our standpoint, our relationship is not changing with them, including our preparations for the next Super Bowl.” A woman who previously sued musician Sean “Diddy” Combs, alleging she was raped at an awards show after-party in 2000 when she was 13 years old, amended the lawsuit on Sunday to include a new allegation that Jay-Z was also at the party and participated in the sexual assault. Jay-Z, real name Shawn Carter, said the rape allegation made against him is part of an extortion attempt. The 24-time Grammy Award winner called the allegations “idiotic” and “heinous in nature” in a statement released by Roc Nation. The NFL teamed up with Jay-Z’s Roc Nation in 2019 for events and social activism. The league and the entertainment company extended their partnership a few months ago. Kendrick Lamar will perform the Super Bowl halftime show at The Caesars Superdome in New Orleans on February 9. Roc Nation and Emmy-winning producer Jesse Collins will serve as co-executive producers of the halftime show. Beyonce, who is married to Jay-Z, will perform at halftime of the Baltimore Ravens-Houston Texans game at Christmas. “I think they’re getting incredibly comfortable not just with the Super Bowl but other events they’ve advised us on and helped us with,” Mr Goodell said. “They’ve been a big help in the social justice area to us on many occasions. They’ve been great partners.”Furious Cucurella changes cleats after slipping twice to concede early goals, then helps Chelsea win
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